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modi ed general linear model program in which the parameters of interest are estimated and tested for signi cance. Several variations on the procedure of choosing a data transformation matrix have been proposed to eliminate the problematic model identi cation step, and are described later in this section. A basic interrupted time series problem would be to determine whether the average level of the series has changed as a result of the intervention. In such an analysis, two parameters are estimated: L, the level of the series, and DL, the change in level after intervention. A test of signi cance would then examine the hypothesis of prime interest, H0 : DL = 0. In algebraic terms this can be expressed in terms of the general linear model as Z = Xb + a (23.1)

treatment options (Low-Beer et al, 2000; Rabkin, Ferrando, Lin, Sewell, & McElhiney, 2000), HIV disease triggers a host of powerful stressors Treatment and support for individuals experiencing adjustment dif culties not only can improve mental health functioning and quality of life, but also may have direct effects on disease progression In this section, we brie y consider the range of stressors that confront persons living with HIV disease, the impact these stressors have on disease progression, and several exemplar studies suggesting promising intervention approaches to improve coping and psychological adaptation among persons living with HIV HIV-Related Stressors Persons living with HIV experience a wide range of stressors throughout the course of their illness Although the nature and severity of psychological distress and coping dif culties vary from person to person, several distinct phases of the illness are commonly associated with increased anxiety and depressive symptoms (Kalichman, 1998).

Thus, let us suppose that one knows a reference con guration of stars (or the position of the Sun or Moon) at a given time and for a given well-known location (eg, Greenwich) If you stay at the same latitude, then you will be able to observe the same con guration but at another time (later if you are eastward and earlier if westward); the difference in times directly gives the longitude, as long as the time of the reference location (Greenwich in the present example) has been kept The longitude is simply obtained by multiplying this difference by 158 per hour, eastward or westward The method is.

Receipt of a positive test result, even if it was expected, is described by many as being among the most challenging and stressful periods of adaptation faced during the course of the illness Individuals often experience a mixture of shock, denial, guilt and fear, as well as concerns about whether to disclose the illness to others (Ostrow et al, 1989) During this initial phase, patients must also consider a bewildering array of options with regard to the initiation of treatment, including the dif cult issue of when to start HAART Emotional distress is often most intense during the rst months of HIV infection, but prospective studies indicate that symptoms of depression and anxiety often decline in the months following HIV test noti cation (Rabkin et al, 1991).

Distress during the asymptomatic phase of HIV disease often results from the multiple uncertainties of future health decline, impaired occupational functioning, high costs of medical care, and declining social supports The rst signs and symptoms of HIV disease progression often lead to a resurgence of more extreme anxiety and depressive symptoms that can often persist inde nitely as patients cope with the uncertainties associated with potential progression to AIDS Finally, the actual diagnosis of AIDS is often experienced as being very traumatic, because it can signify the beginning of the end for patients facing likely death Severe distress associated with an AIDS diagnoses is often short-lived (Rabkin et al, 1997), suggesting that many people with AIDS show an extraordinary capacity to adapt to advancing disease.

Regardless of disease stage, other stressors commonly experienced by persons living with HIV include the challenge of accessing and paying for medical care, experiences of stigmatization, and bereavement associated with the loss of other loved ones to AIDS (for a review, see Kalichman & Catz, 2000)..

The second rationale proposed as the mechanism underlying other-oriented and cooperative behaviors Wilson terms soft-core altruism to represent his belief that the bestower s actions are ultimately self-serving. The original line of reasoning here stems from Trivers s (1971) notion of reciprocity, a thesis suggesting that genetically based dispositions to

choice to minimize the path length for individual nodes, the total number of message transmissions remains suboptimal On the other hand, reducing bandwidth usage can be obtained by sending along a single path as long as possible, that is, the message will be duplicated only if no neighbor node exists that is closer to all the destination nodes considered However, it can be observed that splitting a packet too late may again increase the total number of hops Mauve et al derived an optimization criterion for greedy multicast forwarding that combines both objectives into one expression The function described in ref [24] depends on a parameter l within [0, 1] that can be used to bias the expression between both extremes.

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