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of Italy and Russia invested more in research and development than the amount provided by their respective industrial sectors. The pharmaceutical industry in the United States is the leading source of nancing for pharmaceutical R&D. The European Union and Japan are the next largest investors, as shown in Figure 6.15. In the decade from 1990 to 2000, pharmaceutical R&D investment in the United States in creased 11.4 percent per annum, compared to an increase of 7.3 percent in the European Union and 4 percent in Japan, according to the PhRMA Annual Membership Survey 2002, the European Federation of Pharma ceutical Industries and Associations (EFPIA), and the Japan Pharmaceuti cal Manufacturers Association (JPMA). When adjusted for in ation, the United States investment in research and development was double that of the European Union. According to EFPIA, 15 of the top 40 pharmaceutical companies in terms of R&D expenditure are in the European Union, 13 are in the United States, and 12 are in Japan. In addition, the National Science Foundation reports that about 60 percent of research and development funding in the United States in 2000 was spent on development, with the remaining

1iw at a + 1iwoBt B + nG(a + at)(B + Bt),

Credit $1,000

(7.34) (7.35)

= n;a az + nn(a + at)(a + at),

1950 1960 1970 1980 1990 2000

Of ce Expense Rent Payable (To record rent expense for the month of February)

g;'.

(7.36)

It was Hopfield who first studied a quantum-mechanical model of a dielectric medium [297, 298]. He named the atomic medium quanta (i.e., that of the bare operators nwob)bj ) polaritons because they are energy quanta ofthe polarization field, as photons are energy quanta of th~ li~ht field. Here we will call polaritons the quanta of the collective operator nwoBt B, for reasons that will become apparent in Section 7.3. Hopfield also worked out the normal modes (i.e., the polariton-photon dressed operators). Let us do this now. We define two pairs of dressed annihilation and creation operators given by

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In QuickBooks, the original point of entry for a transaction is not the traditional two-column journal. Rather, entries are recorded as checks and invoices. QuickBooks has a special General Journal Form for transactions that are not conveniently entered on the standard forms, such as the sale of a depreciated asset (see Figure 4-9). If you make adjustments directly to asset or liability account registers, QuickBooks labels them as GENJRNL.

(7.37) with k = 1,2, satisfying the usual commutation relations,

money split almost evenly between basic and applied research. Further more, about 75 percent of the R&D work was performed by industry, while universities and colleges performed 11 percent of the work, as shown in Figure 6.16. Federally funded research and development centers (FFRDCs), which are administered by industrial, academic, and nonpro t institutions, performed 4 percent of the research and development work in 2000. Nonpro t institutions performed 3 percent of the work.

[ek, el, 1= ow,

The traditional terms debits, credits, and T accounts have only marginal relevance to the QuickBooks user. T account refers to a two-column journal format. The debit side of the T account is the left side. The credit side is the right side. Every transaction must be recorded in two parts, a debit and a credit, so there is a corresponding and offsetting increase or decrease in two different accounts for every transaction entered. For example, a cash payment results in an increase in the cash account and a decrease in accounts receivable. Debit refers to the process of increasing an expense or asset or decreasing a liability equity or revenue account by making an entry in the left column of the T account format. A credit, which is an entry in the right column of the T account, increases liabilities, revenues, and equity. Credits also decrease assets and expenses. These rules are summarized in Table 4-1. This system of recording transactions by using offsetting entries and a two-column format showing debits and credits is traditionally known as double-entry bookkeeping. QuickBooks automatically debits and credits the appropriate accounts when you enter a transaction, freeing you from the need to understand debits and credits.

and diagonalizing flo,

(7.38) (7.39)

Government investment in biotech may lag behind industry, but it remains a signi cant factor in the success of virtually every biotech company. One reason for this connection between success and government funding is that private investment, venture capital, and other nancing tends to follow companies that enjoy government support.

Debits Increase: Expense Accounts Asset Accounts: Revenue Accounts Decrease: Liability Accounts Equity Accounts Revenue Accounts Credits Increase: Liability Accounts Equity Account Decrease: Expense Accounts Asset Accounts

[ek' flo]

(7.40)

From (7.3), (7.15), (7.37), (7.38), and (7.40), we find that"

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