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that the structures of the limbic system (the Papez circuit) are concerned with motivation and emotion However, modern neuroanatomy deconstructed the Papez circuit The emphasis is now on the hypothalamus-pituitary axis, on descending neural systems, and on the amygdala Motivation Today most workers in the eld prefer the term motivated behaviors to emphasize the speci c features of behaviors relating to hunger, thirst, sex, temperature, and so forth Karl Lashley was again a prime mover His 1938 paper, Experimental Analysis of Instinctive Behavior, was the key He argued that motivated behavior varies and is not simply a chain of instinctive or re ex acts, is not dependent on any one stimulus, and involves central state His conclusions, that physiologically, all drives are no more than expression of the activity of speci c mechanisms and that hormones activate some central mechanism which maintains excitability and activity, have a very modern ring.

Several key gures in the modern development of the psychobiology of motivation are Clifford Morgan, Eliot Stellar, Kurt Richter, Frank Beach, Neal Miller, Philip Teitelbaum, and James Olds Morgan went to graduate school at Rochester, where his professors included E A K Culler and K U Smith and his fellow graduate students included D Neff, J C R Licklider, and P Fitts He then became an instructor at Harvard, where he rst worked in Lashley s laboratory in 1939 He later moved to Johns Hopkins, where he remained until 1959 As a graduate student and later at Harvard, Morgan came to doubt Cannon s then current notion that hunger was the result of stomach contractions Morgan did a series of studies showing this could not be a complete or even satisfactory account of hunger and feeding behavior Eliot Stellar and Robert McCleary, then undergraduates at Harvard, worked with Morgan.

They focused on hoarding behavior and completed a classic analysis of the internal and environmental factors controlling the behavior Lashley s general notion of a central mechanism that maintains activity was developed by Beach in an important series of papers in the 1940s and by Morgan in the rst edition of his important text, Physiological Psychology (1943), into a central excitatory mechanism and ultimately a central theory of drive This view was given a solid physiological basis by Donald B Lindsley from the work he and H W Magoun, G Moruzzi, and associates were doing on the ascending reticular activating system Lindsley sketched his activation theory of emotion in his important chapter in the Stevens Handbook (1951) Hebb (1955) and Stellar (1954).

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women (ie, whether they regard their sexuality in a positive light) is a signi cant predictor of sexual adjustment after cancer, whereas women with a negative self-schema were less likely to resume sex or have good sexual functioning after treatment for gynecologic cancer (Anderson, Woods, & Copeland, 1997) Physical factors from the cancer treatment itself can contribute greatly to the patient s sexual dysfunctions Chemotherapy, radiation, surgery, opiate and pain medications, antidepressant or antipsychotic medications can cause sexual dysfunctions, as well as infertility, in patients For example, in men receiving prostatectomies, 85% to 90% experience erectile impotence (von Eschenbach, 1986) Loss of sexual desire may be a result of fatigue, pain, or weakness secondary to the cancer treatment, depression, body image concerns, and feelings of guilt or misbeliefs about the development and spread of cancer (Schover, 1997).