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Geographic leashes require loose time synchronization among the nodes in the network, as opposed to temporal leashes, where the nodes in the network need to have tightly synchronized clocks with nanosecond precision In addition, temporal leashes might not be practical in networks (such as those based on the use of 80211) that make use of a contention-based MAC protocol Temporal leashes will also be effective only against the rst and easier mode of tunneling, where a packet is encapsulated Of course, nodes in systems dependent on geographic leashes need to be able to determine their locations securely (see 7) Another approach for detecting wormhole attacks is given in [72] In this case the authors assume the presence of directional antennae The approach here is based on the use of packet arrival direction to detect that packets are arriving from the proper neighbors Such information is possible due to the use of directional antennae This information about the direction of packet arrival is expected to lead to accurate information about the set of neighbors of a node As a result, wormhole attacks can be detected since such attacks emanate from false neighbors To illustrate this idea consider Figure 431 Here we show two nodes, A and B We show the directional antenna with six zones explicitly for both nodes Each node is assumed to have knowledge of the zone from where a packet is received Given this, the basic idea that is used to determine the set of authentic neighbors is that, if a node is in a given direction of another node, then the latter node is in the opposite direction of the former node For example, in Figure 431, node B is in zone 6 of node A while node A is in the opposite zone, which is zone 3 of node B An implicit assumption here is that the directional antennae on the various nodes are perfectly aligned Now consider nodes A, B, C, D, and E as shown in Figure 432 Assume that B transmits a message (call it a Hello message for simplicity) in its neighborhood which includes C Then node C replies back to B informing node B of the zone from which node B s hello message was received If node B receives this reply in the opposite zone to what zone C reports, then node C can possibly be an authentic neighbor Thus, in this case node C replies back to node B that the hello message was received in zone 1 of node C This reply is received by node B in its zone 4, which is the zone opposite to zone 1 Thus, B can infer that node C is an authentic neighbor Every node can repeat this and form the list of authentic neighbors Any message that does not emanate from an authentic neighbor is rejected.

Testosterone has also been associated with general mood-elevating effects Some studies have found associations between lowered T levels and depressive symptoms [139,140] Depression is not rare in aging men, and impairs their quality of life [139]; so the effects that declining levels of androgens may have on mood and on speci c aspects of cognitive functioning in aging are well-worth researching However, although low T was recently observed to predict incident depressive illness in older men in a longitudinal study [141], and a signi cant relation between depression and androgen receptor CAG repeat length has been reported in men aged 48 79 years [142], only two of the nine RCTs that have assessed the effects of T therapy on mood in aging men found a signi cant improvement in depression scores compared with placebo [87] Combined therapy with T has also been observed to improve the ef cacy of anti-depressant agents over placebo in small groups of younger men with refractory depression [143]

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3 Jeanne Lambrew, Consumer-Driven Health Plans Prevent Prevention, Center for American Progress, April 10, 2008, http://wwwamericanprogressorg/issues/2008/04/prevention html/#article1 4 Lee Jong-wook, Launch of the Chronic Disease Report 5 Angela Zimm, Bloomberg News, Chronic Illnesses on Rise, Study Says, Boston Globe, June 27, 2007, http://wwwbostoncom/news/ nation/articles/2007/06/27/chronic_illnesses_on_rise_study_says/ 6 J A Poisal et al, Health Spending Projections Through 2016: Modest Changes Obscure Part D s Impact, Health Affairs, February 21, 2007, W242 253 7 For scal year 2009, Medicare (the US government program that supports 44 million elderly and disabled) will receive $420 billion in federal funding, while Medicaid (which provides health coverage and long-term care assistance to over 44 million low-income individuals and 14 million elderly and disabled people) will receive $224 billion 8 P T Huynh, C Schoen, R Osborn, and A L Holmgren, The US Health Care Divide: Disparities in Primary Care Experiences by Income, Commonwealth Fund, April 2006 9 Michael D Tanner, The Grass Is Not Always Greener: A Look at National Health Care Systems Around the World, Policy Analysis 613, March 18, 2008, http://wwwcatoorg/pub_display php pub_id=9272 10 Justi cation of Estimates for Appropriation Committees, Centers for Disease Control and Prevention, Department of Health and Human Services Fiscal Year 2009, http://wwwhhsgov/budget/ docbudgethtm#brief 11 Ibid 12 China Accused of Sars Cover-Up, BBC News, April 9, 2003, http://newsbbccouk/2/hi/health/2932319stm 13 Brian Knowlton, 2 Flights Carried Man with Deadly TB, New York Times, May 29, 2007, http://wwwnytimescom/2007/05/29/ health/29cnd-tbhtml _r=1&ref=health&oref=slogin 14 Jeanne M Lambrew and John D Podesta, Promoting Prevention and Preempting Costs: A New Wellness Trust for the United States, Center for American Progress, October 5, 2006, 3

Earlier studies have questioned the relevance of estrogens in human male sexuality [144] A recent study found that estrogen replacement in an aromatase-de cient man increased libidinous aspects of sexuality [145] There is also a range of non-sexual effects of androgens on the brain and for (some of) these effects aromatization of androgen to estrogens might be relevant Indeed, effects of estrogen on the brain are increasingly being recognized [146], though studies have mainly been carried out using animal models Estrogens have been observed to in uence many processes in many regions of the brain throughout the entire life span These effects include those on cognitive function, co-ordination of movement, pain, and affective state, involving both the

Hormones, Metabolism, Aging, and Men s Health estrogen receptor (ER)- and ER- genes Only some of the estrogen actions on the brain are intracellularly receptor-mediated, while others take place on the cell membrane, mediated via second messenger mechanisms, neuronal excitability, and ion channels [147]

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